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Survival analysis and literature mining were used to verify our results and provided a theoretical basis for further research. Using bioinformatics technology to analyze DEGs, combined with Oncomine database to screen potential molecular targets suitable for early diagnosis and immunotherapy of liver cancer.
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In this study, the original data was downloaded from the TCGA database, and the R software was used to screen the differentially expressed genes (DEGs) in the gene expression profile of liver cancer tissues and adjacent tissues. Therefore, screening markers related to early diagnosis, invasion and metastasis of liver cancer is of great significance for improving the therapeutic effect and prognosis of liver cancer. At present, the commonly used diagnostic methods of liver cancer, such as serological tumor markers and imaging techniques, are not satisfactory in clinical effect. Early detection and treatment can effectively improve the prognosis of tumor patients and reduce the mortality rate, but there are usually no obvious clinical symptoms in the early stage of liver cancer. Data show that about 70% of liver cancers relapse within 5 years after resection or ablation. However, as the underlying mechanism of liver cancer is still unclear, liver cancer has a high incidence, strong invasiveness and poor prognosis. Current treatments for liver cancer mainly include surgery and intervention, etc. Here we presented a new method to identify the 6 key genes for diagnosis and treatment of early liver cancer, and these key genes can help us understand the pathogenesis of liver cancer more deeply.Īs one of the common malignant tumors in China, liver cancer accounts for 70–80% of primary liver malignancies, and are the second leading cause of cancer-related mortality. ConclusionsĪlthough there are complicated differences between cancer and normal cells in gene functions, cancer cells could be differentiated in case that a group of special genes expresses abnormally. The robustness analysis of four independent data sets verifies the accuracy of the key gene’s classification of the data set. Finally, 15 hub genes were verified by applying the survival analysis method on Oncomine database, and 6 key genes were ultimately identified, including PLK1, CDC20, CCNB2, BUB1, MAD2L1 and CCNA2. Furthermore, these differentially expressed genes were studied by using GO and KEGG enrichment analysis, a PPI network was constructed based on the STRING database, and 15 hub genes were obtained.

We firstly analyzed the different expression microarrays based on TCGA database, and a total of 1564 differentially expressed genes were obtained, of which 1400 were up-regulated and 164 were down-regulated.

Here we present a new method for getting 6 key genes, aiming to diagnose and treat the early liver cancer. However, the hub genes, which can be served as biomarkers for diagnosis and treatment of early liver cancer, are not well screened. Its occurrence and development were thoroughly studied by high-throughput expression microarray, which produced abundant data on gene expression, mRNA quantification and the clinical data of liver cancer. and other countries.Liver cancer is a common malignant tumor in China, with high mortality. iTunes is a trademarks of Apple Inc, registered in the U.S.
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Its hardware component connects via USB and does not require driver installation or a power adapter.
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Do you need a power adapter for discover dj?ĭiscover DJ works plug-and-play with Mac and PC computers. Just load your tracks to either Deck A or Deck B, and then control it, cueing up the start point, performing advanced transitions and even scratching. On screen, the MixVibes CROSS LE software is a virtual extension of the DISCOVER DJ hardware, with two decks. How does mixvibes cross le work on discover dj? Discover DJ consists of a hardware DJ control surface with a convenient, standard USB connection and powerful MixVibes Cross LE performance DJ software. The DJ system harnesses the processing power of your Mac or PC and enables you to DJ parties, events and even clubs using the music that is already on your computer. What do you need to know about discover dj? Secondly, the needs of users are growing, requirements are increasing and the needs are changing for ion discover dj software download.

First, new technologies are emerging, as a result, the equipment is being improved and that, in turn, requires software changes.
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Update for ion discover dj software download. Frequently Asked Questions Is there an update for ion discover dj?
